- Main article: Human-Covenant war
Prior to 2535 Jacob Keyes served aboard this vessel. At one point, he defended the vessel against an overwhelming Covenant attack force with only a small security team. These actions awarded him a Medal of Honor.
- The Meriwether Lewis is named after the famous explorer of the same name who, along with William Clark, mapped out most of the Western United States in the early 1800s.
- In the Halo: Combat Evolved manual, this ship was classified as a Colony Ship. For more information see: List of inconsistencies in Halo.
- Halo: Combat Evolved
- Halo: Combat Evolved Instruction Manual (Mentioned only)
- Halo: The Fall of Reach (Mentioned only)
- Halo: The Cole Protocol (First appearance)
- ↑ Halo: The Cole Protocol - Page 28
- ↑ Halo 5: Guardians Limited Edition - Bonus Item: Edward Buck Dossier Card